Drug device combination is combining two or more different
types of products including medical devices, biologics and drugs. With drug
device combination products there is an increase in overall efficacy and percentage
of patients who respond. The efficacy depends upon the pharmacodynamics and
pharmacokinetic properties of the drug used in combination. There are different
types of drug device combination products. In case of infusion pumps, fluids
such as nutrients and medications are administered into a patient’s body in
controlled amounts. Next drug device combination product is inhaler which helps
in administering drug to a patient via lungs. Further, transdermal patch is an
adhesive pad which is placed on skin to administer a time released dose of
medication directly into the bloodstream via skin. In case of drug eluting
stents such as urethral stents, the stent is coated with medicines such as
heparin which is an anti-coagulating agent. This stent maintains the urinary
flow from the kidney to the bladder while avoiding coagulation. Another drug
device combination product is orthopedic drug combination product such as
antibiotic bone cement which is used for treating infected joint
arthroplasties. Next combination product is drug device combination, in which
duration of action of a drug and intensity is increased. It reduces the dosage
frequency and improves patient compliance. Wound care products are used in
managing wounds. In case of photodynamic therapy devices, a photosensitizer and
a type of light is used to treat tumors on the skin.
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The major factor driving the growth of drug devices market
is increase in the prevalence of chronic diseases. According to European
Academy of Allergy and Clinical Immunology (EAACI), in 2013, around 300 million
people were suffering from asthma and the number is expected to increase by 100
million by 2025. In terms of global years lived with disability, the Global
Asthma Network states that asthma is the 14th most important medical
condition worldwide. Further, it also states that, asthmatic symptoms are
experienced by 14% of the total children population across the world.
Additionally, increase in the adoption of point of care treatments will also
boost this market. Moreover, increase in the geriatric population will also
drive this market. For instance, according to WHO, in 2015, 900 million people were 60 years
of age or older and the number is expected to reach up to 2 billion by 2050.
The key strategy followed by the major players in the drug
device combination market is product launch to gain competitive advantage and
more market share. For instance, in 2016, AstraZeneca’s Bevespi Aerosphere was
approved by the FDA for patients with COPD. It is a metered dose inhaler which
contains combination of two drugs, namely, glycopyrrolate and formoterol
fumarate. With the launch of this drug AstraZeneca will gain competitive
advantage and more share in the market.
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The major players in the drug
device market are Medtronic, Terumo Corporation, W. L. Gore & Associates,
Inc., C.R. Bard, Inc., Johnson & Johnson Private Limited, Stryker
Corporation, Medline, Medtronic, Mylan Inc., and, Becton, Dickinson and
Company, and Pinnacle Biologics.
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